Establishment of a prediction model for severe acute radiation enteritis associated with cervical cancer radiotherapy
作者机构：Radiation OncologyThe First Affiliated Hospital of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina State Key Laboratory of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123Jiangsu ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2023年第29卷第8期
页 面：1344-1358页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 10[医学]
基 金：the National Natural Science Foundation of China,No.81602792 and No.81602802 Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University,No.GZK1202101 Suzhou Science and Technology Development Plan Project,No.KJXW2020008 BOXI Natural Science Cultivation Foundation of China of the First Affiliated Hospital of Soochow University,No.BXQN202107
主 题：Cervical cancer Intensity-modulated radiotherapy Radiation enteritis Nomogram Predictor
摘 要：BACKGROUND Cervical cancer is one of the most common gynecological malignant *** enteritis(RE)leads to radiotherapy intolerance or termination of radiotherapy,which negatively impacts the therapeutic effect and seriously affects the quality of life of *** the incidence of RE in patients can be predicted in advance,and targeted clinical preventive treatment can be carried out,the side effects of radiotherapy in cervical cancer patients can be significantly ***,accurate prediction of RE is essential for the selection of individualized radiation dose and the optimization of the radiotherapy *** To analyze the relationships between severe acute RE(SARE)of cervical cancer radiotherapy and clinical factors and dose-volume parameters *** We included 50 cervical cancer patients who received volumetric modulated arc therapy(VMAT)from September 2017 to June 2018 in the Department of Radiotherapy at The First Affiliated Hospital Soochow *** and dose-volume histogram factors of patients were *** regression analysis was used to evaluate the predictive value of each factor for SARE.A nomogram to predict SARE was developed(SARE scoring system≥3 points)based on the multiple regression coefficients;validity was verified by an internal verification *** Gastrointestinal and hematological toxicity of cervical cancer VMAT gradually increased with radiotherapy and reached the peak at the end of *** main adverse reactions were diarrhea,abdominal pain,colitis,anal swelling,and blood in the *** was no significant difference in the incidence of gastrointestinal toxicity between the radical and postoperative adjuvant radiotherapy groups(P0.05).There were significant differences in the small intestine V_(20),V_(30),V_(40),and rectal V40 between adjuvant radiotherapy and radical radiotherapy after surgery(P0.05).Univariate and multivariate analyses revealed anal bulge r
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