Exposure to proton pump inhibitors and risk of diabetes:A systematic review and meta-analysis

作     者：Yun-Ran Guo Xin-Ming Liu Gui-Xia Wang 

作者机构：Department of Endocrinology and MetabolismThe First Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2023年第14卷第2期

页      面：120-129页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Proton pump inhibitors Diabetes mellitus Odds ratio Meta-analysis Diabetogenesis 

摘      要：BACKGROUND Exposure to proton pump inhibitors(PPIs)has been reported to have a potential role in the development of *** To determine the association between PPIs and *** This meta-analysis is registered on PROSPERO(CRD42022352704).In August 2022,eligible studies were identified through a comprehensive literature *** this study,odds ratios were combined with 95%confidence intervals using a random-effects *** source of heterogeneity was assessed using sensitivity analysis and subgroup *** publication bias was evaluated using Egger’s test and Begg’s *** The meta-analysis included 9 studies with a total of 867185 *** showed that the use of PPIs increased the risk of diabetes(odds ratio=1.23,95%confidence interval:1.05-1.43,n=9,I2=96.3%).Subgroup analysis showed that geographic location and study type had significant effects on the overall *** Egger’s and Begg’s tests showed no publication bias(P0.05).Sensitivity analysis also confirmed the stability of the *** The results of this study indicated that the use of PPIs was related to an increased risk of ***,more well-designed studies are needed to verify these results in the future.