RNA methylation into m^(1)A era:a new regulation over T-cell function

作     者：Ping Lin Guoping Li Min Wu Ping Lin;Guoping Li;Min Wu

作者机构：Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City&Southwest UniversityBiological Science Research CenterSouthwest University400715ChongqingChina Wound Trauma Medical CenterState Key Laboratory of TraumaBurns and Combined InjuryDaping HospitalArmy Medical University400042ChongqingChina Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang325000China Laboratory of Allergy and Precision MedicineChengdu Institute of Respiratory HealthThe Third People’s Hospital of Chengdu610014ChengduSichuanChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第3期

页      面：881-882页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was jointly supported by research grants from the National Nature Science Foundation of China(32000033 and 82020108021) the National Key Research and Development Program of China(Grant No.2022YFD1201600) Wenzhou Institute University of Chinese Academy of Sciences,and Fundamental Research Funds for the Central Universities(SWU-KR22013) 

主　　题：al. inflammation Immunology 

摘      要：In a recent paper published in Nature Immunology,Liu et *** that the“writersTRMT6/TRMT61A complex mediated transfer RNA(tRNA)m1A modification,facilitating competent translation of certain proteins fundamental to T-cell proliferation in an instant upon activation,1 demonstrating that tRNA m^(1)A methylation as a crucial translational checkpoint paves the way for novel immunotherapies to treat T-cell-related inflammation or cancer via manipulating the m^(1)A machinery.