PD-1/PD-L1 Signaling Pathway and Tumor Immune Escape
PD-1/PD-L1 Signaling Pathway and Tumor Immune Escape作者机构：Department of Oncology The First Affiliated Hospital of Yangtze University Jingzhou China
出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)
年 卷 期：2023年第11卷第3期
页 面：9-16页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Programmed Death 1 Programmed Death Ligand 1 Neoplasms Immunotherapy
摘 要：PD-1 and its ligands PD-L1 and PD-L2 are widely expressed on the surface of a variety of cells and are a group of costimulatory molecules related to negative immune regulation. The activation of the PD-1/PD-L1 signaling pathway is beneficial for tumors to escape from immune surveillance, but the specific tumor immune escape mechanism is not yet clear. As far as the efficacy of anti-PD-1 and anti-PD-L1 antibodies is concerned, more in-depth research on tumor immune escape mechanisms is still needed. The article summarizes these findings to provide ideas for antitumor immunotherapy.
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