Experimental validation for time-domain fluorescence diffuse optical tomography of linear scheme

作     者：高峰 张丽敏 李娇 赵会娟 

作者机构：College of Precision Instrument and Optoeletronics Engineering Tianjin University 

出 版 物：《Chinese Optics Letters》 (中国光学快报（英文版）)

年 卷 期：2008年第6卷第12期

页      面：889-892页

核心收录：

学科分类：070207[理学-光学] 07[理学] 08[工学] 0803[工学-光学工程] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(No.60578008,60678049) the National Basic Research Program of China(No.2006CB705700) Tianjin Municipal Government of China(No.07JCYBJC06600) 

主　　题：Diagnostic radiography Image segmentation Medical imaging Optical tomography Three dimensional Time domain analysis Tomography 

摘      要：We present a full three-dimensional, featured-data algorithm for time-domain fluorescence diffuse optical tomography that inverts the Laplace-transformed time-domain coupled diffusion equations and employs a pair of appropriate transform-factors to effectively separate the fluorescent yield and lifetime parameters. By use of a time-correlation single-photon counting system and the normalized Born formulation, we experimentally validate that the proposed scheme can achieve simultaneous reconstruction of the fluorescent yield and lifetime distributions with a reasonable accuracy.