Alternative signal priming enhances the inflammatory response in macrophages

作     者：Huihao Tang Xiaojie Li Taomin Huang Xiaolei Ding 

作者机构：Institute of GeriatricsAfliated Nantong Hospital of Shanghai University(The Sixth People's Hospital of Nantong)School of MedicineShanghai UniversityNantong 22611 China Shanghai Engineering Research Center of Organ RepairSchool of MedicineShanghai UniversityShanghai 200444China Department of PharmacyEye&ENT HospitalFudan UniversityShanghai 200031China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2023年第20卷第7期

页      面：689-691页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：the National Natural Science Foundation of China(No.82272278) 

主　　题：inflammatory al. landscape 

摘      要：A recent study by Czimmerer et *** in Immunity reveals that exposure to interleukin-4(IL-4),which is an alternative signal,remodels the macrophage epigenetic landscape,including chromatin structure and the binding of transcriptional regulators to their dedicated *** allows for a synergistic interaction with toll-like receptor(TLR)ligand-mediated inflammatory stimuli,consequently enabling these cells to have an exaggerated inflammatory response[1].