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文献详情 >Inactivation of ERK1/2-CREB Pa... 收藏

Inactivation of ERK1/2-CREB Pathway Is Implicated in MK801-induced Cognitive Impairment

作     者:Cui-ping GUO Wen-sheng Li Yi LIU Yacoubou Abdoul Razak Mahaman Bin ZHANG Jian-zhi WANG Rong LIU Hong-lian LI Xiao-chuan WANG Xiang GAO Cui-ping GUO;Wen-sheng LI;Yi LIU;Yacoubou Abdoul Razak Mahaman;Bin ZHANG;Jian-zhi WANG;Rong LIU;Hong-lian LI;Xiao-chuan WANG;Xiang GAO

作者机构:Central LaboratoryScientific Research DepartmentRenmin Hospital of Wuhan UniversityWuhan430060China Co-innovation Center of NeuroregenerationNantong UniversityNantong226001China Department of PathophysiologySchool of Basic MedicineKey Laboratory of Education Ministry/Hubei Province of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Shenzhen Huazhong University of Science and Technology Research InstituteShenzhen518000China 

出 版 物:《Current Medical Science》 (当代医学科学(英文))

年 卷 期:2023年第43卷第1期

页      面:13-21页

核心收录:

学科分类:1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基  金:supported in part by grants from National Natural Science Foundation of China(No.31929002,No.82201326 No.82071440 and No.92049107) Science,Technology and Innovation Commission of Shenzhen Municipality(No.JCYJ20210324141405014) Guangdong Basic and Applied Basic Research Foundation(No.2020B1515120017) the Academic Frontier Youth Team Project to Xiao-chuan WANG from Huazhong University of Science and Technology 

主  题:schizophrenia cognitive impairments cAMP response element binding protein ERK1/2 MK801 

摘      要:Objective Schizophrenia(SZ)is associated with cognitive impairment,and it is known that the activity of cAMP response element binding protein(CREB)decreases in the brain of SZ *** previous study conducted by the investigators revealed that the upregulation of CREB improves the MK801-related SZ cognitive *** present study further investigates the mechanism on how CREB deficiency is associated with SZ-related cognitive *** MK-801 was used to induce SZ in *** blotting and immunofluorescence were performed to investigate CREB and the CREB-related pathway implicated in MK801 *** long-term potentiation and behavioral tests were performed to assess the synaptic plasticity and cognitive impairment,*** The phosphorylation of CREB at Ser133 decreased in the hippocampus of SZ ***,among the upstream kinases of CREB,merely ERK1/2 was downregulated,while CaMKII and PKA remained unchanged in the brain of MK801-related SZ *** inhibition of ERK1/2 by PD98059 reduced the phosphorylation of CREB-Ser133,and induced synaptic dysfunction in primary hippocampal ***,the activation of CREB attenuated the ERK1/2 inhibitor-induced synaptic and cognitive *** These present findings partially suggest that the deficiency of the ERK1/2-CREB pathway is involved in MK801-related SZ cognitive *** activation of the ERK1/2-CREB pathway may be therapeutically useful for treating SZ cognitive deficits.

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