Excess mortality associated with high ozone exposure:A national cohort study in China
作者机构：Institute of Social Development and Health ManagementHubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of Public HealthWuhan University of Science and TechnologyWuhan430065China Centre for Atmospheric ScienceYusuf Hamied Department of ChemistryUniversity of CambridgeCambridgeCB21EWUK Department of Earth SciencesUniversity of CambridgeCambridgeCB23EQUK Department of Environmental Science and EngineeringSichuan UniversityChengduSichuan610065China School of Economics and ManagementUniversity of Science and Technology BeijingBeijing100083China Department of Big Data in Health ScienceSchool of Public HealthZhejiang UniversityHangzhou310058China
出 版 物：《Environmental Science and Ecotechnology》 (环境科学与生态技术（英文）)
年 卷 期：2023年第15卷第3期
页 面：98-105页
核心收录：
学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 10[医学]
主 题：Ozone Long-term exposure All-cause mortality Cohort study
摘 要：Emerging epidemiological studies suggest that long-term ozone(O_(3))exposure may increase the risk of mortality,while pre-existing evidence is mixed and has been generated predominantly in North America and Europe.In this study,we investigated the impact of long-term O_(3)exposure on all-cause mortality in a national cohort in China.A dynamic cohort of 20882 participants aged40 years was recruited between 2011 and 2018 from four waves of the China Health and Retirement Longitudinal Study.A Cox proportional hazard regression model with time-varying exposures on an annual scale was used to estimate the mortality risk associated with warm-season(Aprile September)O_(3)exposure.The annual average level of participant exposure to warm-season O_(3)concentrations was 100 mg m^(-3)(range:61 e142 mg m^(-3)).An increase of 10 mg m^(-3)in O_(3)was associated with a hazard ratio(HR)of 1.18(95%confidence interval[CI]:1.13e1.23)for all-cause mortality.Compared with the first exposure quartile of O_(3),HRs of mortality associated with the second,third,and highest exposure quartiles were 1.09(95%CI:0.95e1.25),1.02(95%CI:0.88e1.19),and 1.56(95%CI:1.34e1.82),respectively.A J-shaped concentration eresponse associationwas observed,revealing a non-significant increase in risk below a concentration of approximately 110 mg m^(-3).Low-temperature-exposure residents had a higher risk of mortality associated with long-term O_(3)exposure.This study expands current epidemiological evidence from China and reveals that high-concentration O_(3)exposure curtails the long-term survival of middle-aged and older adults.
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