Signaling pathways in Parkinson’s disease:molecular mechanisms and therapeutic interventions
作者机构：College of Pharmaceutical SciencesZhejiang University310058 HangzhouP.R.China State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacaoP.R.China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第3期
页 面：1094-1111页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：The study was supported by the National Key Research and Development Program of China(2022YFC3501904,2021YFC1712805) Zhejiang province commonweal projects(TGY23H090038,LG F22H280001) the Key Project at Central Government Level(2060302),and the Macao Science and Technology Development Fund,Macao Special Administrative Region,China
主 题：therapeutic mechanisms summarized
摘 要：Parkinson’s disease(PD)is the second most common neurodegenerative disease worldwide,and its treatment remains a big *** pathogenesis of PD may be related to environmental and genetic factors,and exposure to toxins and gene mutations may be the beginning of brain *** identified mechanisms of PD includeα-synuclein aggregation,oxidative stress,ferroptosis,mitochondrial dysfunction,neuroinflammation,and gut *** interactions among these molecular mechanisms complicate the pathogenesis of PD and pose great challenges to drug *** the same time,the diagnosis and detection of PD are also one of obstacles to the treatment of PD due to its long latency and complex *** conventional therapeutic interventions for PD possess limited effects and have serious side effects,heightening the need to develop novel treatments for this *** this review,we systematically summarized the pathogenesis,especially the molecular mechanisms of PD,the classical research models,clinical diagnostic criteria,and the reported drug therapy strategies,as well as the newly reported drug candidates in clinical *** also shed light on the components derived from medicinal plants that are newly identified for their effects in PD treatment,with the expectation to provide the summary and outlook for developing the next generation of drugs and preparations for PD therapy.
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