Identification of monocyte-related transcriptomic signature of peripheral blood mononuclear cells in type 1 diabetes

作     者：Min Yin Yan Zhang Juan Huang Xinyu Li Haibo Yu Xia Li Min Yin;Yan Zhang;Juan Huang;Xinyu Li;Haibo Yu;Xia Li

作者机构：National Clinical Research Center for Metabolic DiseasesKey Laboratory of Diabetes ImmunologyMinistry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Internal MedicineSection of EndocrinologySchool of MedicineYale UniversityNew HavenCTUSA Hunan Engineering Research Center of Cell Therapy for DiabetesChangshaHunan 410011China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第21期

页      面：2608-2610页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：National Natural Science Foundation of China(No. 82070812) Fundamental Research Funds for the Central Universities of Central South University(No. 2021zzts0361) Hunan Provincial Innovation Foundation for Postgraduate(No. CX20210363) 

主　　题：islet diabetes blood 

摘      要：To the Editor:Type 1 diabetes(T1D)is caused by autoimmunity-mediated destruction of pancreatic islet beta cells,with islet autoimmunity being the essential component in the pathogenesis of T1D.[1]However,studies on human islets are limited due to sampling difficulties.Therefore,immunological changes in peripheral blood mononuclear cells(PBMCs)should be emphasized.In one way,islet-infiltrating immune cells are presumably in equilibrium with circulating pools and changes in PBMCs might partly reflect islet inflammation.On the other,PBMCs represent a useful tool to detect biomarkers for disease.[2]Traditionally,studies on PBMCs in T1D are characterized by the use of limited numbers of cell-surface markers and secreted cytokines measured using flow detection and other antibody-based assays.