Potential of ginsenoside Rh_(2)and its derivatives as anti-cancer agents
作者机构：Key Laboratory of Biotechnology and Bioresources UtilizationMinistry of EducationDalian Minzu UniversityDalian 116600China College of Chinese Medicinal MaterialsJilin Agricultural UniversityChangchun 130118China
出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)
年 卷 期：2022年第20卷第12期
页 面：881-901页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床]
基 金：This work was supports by the National Natural Science Foundation of China(Nos.82173913,81603272,81803492) the High-level Talent Innovation Support Program of Dalian City(No.2017RQ152) Dalian High-level Talent Innovation Support Program-Cutting-edge and Leading Talent(No.2021RD10) the Science and Technology Innovation Foundation of Dalian City(No.2018J12SN062) Key R&D Projects of Liaoning Province(No.2020JH2/10300054) Science and Technology Innovation Foundation of Dalian City(No.2021JJ13SN51) Open Fund of Key Laboratory of Biotechnology and Bioresources Utilization(Dalian Minzu University),Ministry of Education(No.KF2020004).
主 题：Ginsenoside Rh_(2) Anticancer Mechanisms of action Synergistic effect Drug delivery systems
摘 要：As a steroid skeleton-based saponin,ginsenoside Rh_(2)(G-Rh_(2))is one of the major bioactive ginsenosides from the plants of genus Panax L.Many studies have reported the notable pharmacological activities of G-Rh_(2)such as anticancer,antiinflammatory,antiviral,antiallergic,antidiabetic,and anti-Alzheimer’s activities.Numerous preclinical studies have demonstrated the great potential of G-Rh_(2)in the treatment of a wide range of carcinomatous diseases in vitro and in vivo.G-Rh_(2)is able to inhibit proliferation,induce apoptosis and cell cycle arrest,retard metastasis,promote differentiation,enhance chemotherapy and reverse multi-drug resistance against multiple tumor cells.The present review mainly summarizes the anticancer effects and related mechanisms of G-Rh_(2)in various models as well as the recent advances in G-Rh_(2)delivery systems and structural modification to ameliorate its anticancer activity and pharmacokinetics characteristics.
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