Roles of eIF5A in the immunosurveillance of cellular senescence

作     者：Xiangli Jiang Fabricio Loayza-Puch Xiangli Jiang;Fabricio Loayza-Puch

作者机构：Department of Thoracic OncologyTianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Translational Control and MetabolismGerman Cancer Research Center(DKFZ)Heidelberg 69120Germany 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2022年第19卷第11期

页      面：1523-1527页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China (Grant No. 81501988) the DKFZ Clinician Scientist Program,which is sponsored by the Dieter Morszeck Foundation 

主　　题：unstable SASP senescence 

摘      要：Senescence is a cellular stress response program that prevents the proliferation of oncogenically activated, genetically unstable, and/or damaged cells. Senescence was first described in 1961, when normal cultured human fibroblasts were found to enter irreversible growth arrest after multiple cell divisions, in a process known as replicative senescence1. Several types of senescence have since been identified, such as stress-induced senescence, oncogene-induced senescence, and virus-induced senescence. Despite having distinct features due to their different triggers, senescent cells share several key features.