Organoid research on human early development and beyond
作者机构：Biomedical Pioneering Innovation CenterBeijing Advanced Innovation Center for GenomicsSchool of Life SciencesPeking UniversityNO.5 Yiheyuan RoadBeijing 100871China
出 版 物：《Medical Review》 (医学评论（英文）)
年 卷 期：2022年第2卷第5期
页 面：512-523页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the support from the National Key R&D Program of China(2018YFA0107601).
主 题：genome editing implantation microfluidics organoid single cell sequencing tissue engineering
摘 要：The organoid field has been developing rapidly during the last decade.Organoids for human pre-,peri-and post-implantation development have opened an avenue to study these biological processes in vitro,which have been hampered by lack of accessible research models for long term.The technologies of four fields,single cell omics sequencing,genome editing and lineage tracing,micro-fluidics and tissue engineering,have fueled the rapid development of the organoid field.In this review,we will discuss the organoid research on human early development as well as future directions of the organoid field combining with other powerful technologies.
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