Modeling of Mechanisms Providing the Overall Control of Human Circulation
作者机构：Department of“Human Systems Modeling”Cybernetics CenterInstitute of Software Systems of National Academy of SciencesKievUkraine
出 版 物：《Advances in Human Physiology Research》 (人体生理学研究进展（英文）)
年 卷 期：2022年第4卷第1期
页 面：5-21页
主 题：Arterial pressure Angiotensin Baroreflex Chemoreflex Hypertension Renin-angiotensin systems Ischemia Simulation
摘 要：Multiple humoral and nervous mechanisms,each influencing the cardiovascular system(CVS)with its specific dynamics and power,had been evolutionarily saved both in animals and in human *** of such mechanisms are considered to be controllers of CVS’s function,but there is no concept clearly explaining the interaction of global and local controllers in intact human organisms under physiological or pathological *** and ethical constraints create practically insuperable obstacles while experiments on animals mainly concern artificial situations with certain switched-of ***,mathematical modeling and computer simulations provide the most promising way for expanding and deepening our understanding of regulators’*** most of CVS’s models describe only partial control mechanisms,a special model(SM)capable of simulating every combination of control mechanisms is *** paper has three goals:i)to argue the uncial modeling concept and its physiological basis,ii)to describe SM,and iii)to give basic information about SM’s test *** describes human hemodynamics,which is under influence of arterial baroreceptor reflexes,peripheral chemoreceptor reflexes,central(cRAS)and local(lRAS)renin-angiotensin systems,local ischemia,and autoregulation of total brain ***,performed in form of special software(SS),is tested under specific endogenous and/or exogenous *** physiologist using SS can easily construct the desirable configuration of regulator mechanisms,their actual state,and scenarios of computer *** illustrated the adequateness of SM,are the first step of SM’s *** of the interaction of modeled regulator mechanisms have to be illustrated in special publications.
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