Peripheral CD4^(+)CD8^(+) double positive T cells:A potential marker to evaluate renal impairment susceptibility during systemic lupus erythematosus

作     者：Kai Chang Wanlin Na Chenxia Liu Hongxuan Xu Yuan Liu Yanyan Wang Zhongyong Jiang 

作者机构：Department of Medical LaboratoryThe General Hospital of Western Theater CommandChengduSichuan 610083China Institute of MicrobiologySichuan Center for Disease Control and PreventionChengduSichuan 610044China Biology Teaching and Research GroupChengdu Experimental Foreign Languages SchoolChengduSichuan 611134China Department of Medical LaboratoryAffiliated Cancer Hospital of Chengdu Medical CollegeChengdu Seventh People's HospitalChengduSichuan 610231China 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2023年第37卷第1期

页      面：59-68页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Natural Science Foundation of Sichuan Province (Grant No.2022NSFSC1415) the Special Project of Sichuan Province Traditional Chinese Medicine Administration (Grant No. 2020JC0124) the Management Project of General Hospital of Western Theater Command (Grants No. 2021-XZYG-C22 and 2021-XZYG-C21) the Spark Young Innovative Talent Project of General Hospital of Western Theater Command 

主　　题：CD4^(+)CD8^(+)double positive T cells lupus nephritis susceptibility systemic lupus erythematosus 

摘      要：Lupus nephritis(LN) has a high incidence in systemic lupus erythematosus(SLE) patients, but there is a lack of sensitive predictive markers. The purpose of the study was to investigate the association between the CD4^(+)CD8^(+)double positive T(DPT) lymphocytes and LN. The study included patients with SLE without renal impairment(SLE-NRI), LN, nephritic syndrome(NS), or nephritis. Peripheral blood lymphocyte subsets were analyzed by flow cytometry. Biochemical measurements were performed with peripheral blood in accordance with the recommendations proposed by the National Center for Clinical Laboratories. The proportions of DPT cells in the LN group were significantly higher than that in the SLE-NRI group(t=4.012, P0.001), NS group(t=3.240,P=0.001), and nephritis group(t=2.57, P=0.011). In the LN group, the risk of renal impairment increased significantly in a DPT cells proportion-dependent manner. The risk of LN was 5.136 times(95% confidence interval, 2.115–12.473) higher in cases with a high proportion of DPT cells than those whose proportion of DPT cells within the normal range. These findings indicated that the proportion of DPT cells could be a potential marker to evaluate LN susceptibility, and the interference of NS and nephritis could be effectively excluded when assessing the risk of renal impairment during SLE with DPT cell proportion.