Multi-frame speckle reduction in OCT using supercontinuum pumped by noise-like pulses

作     者：Chengming Wang Yi-Jing You Shengnan Ai Wenxin Zhang Wenchao Liao Xiao Zhang Juicheng Hsieh Ning Zhang Bihua Tang Ci-Ling Pan Ping Xue 

作者机构：State Key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghua University Collaborative Innovation Center of Quantum Matter BeijingP.R.China Department of PhysicsNational Tsing Hua University No.101Sec.2Kuang-Fu RdHsinchuTaiwan Department of Physics and Institute of Photonics Technologies National Tsing Hua UniversityTaiwan School of Life Science Beijing Institute of TechnologyBeijingP.R.China Institute of Forensic Science Ministry of Public Security BeijingP.R.China Southwest Medical University LuzhouSichuan ProvinceP.R.China Nuctech Company LimitedBeijingP.R.China 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2019年第12卷第2期

页      面：86-92页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 070207[理学-光学] 0808[工学-电气工程] 07[理学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：This research was supported by the National Natural Science Foundation of China(61227807,61575108 and 61505034) Tsinghua Initiative Scientific Research Program(2013THZ02-3) C.L.Pan and Y.J.You were supported in part by the Ministry of Science and Technology,Taiwan,under Grant 103-2622-E-007-006-CC2 and by the National Tsing Hua University Research Program Grant 104N2711E1.C.L.Pan is also supported by the Air Force Office of Scientific Research FA2386-13-1-4086.The first three authors contribute equally to this paper。 

主　　题：Noise-like pulses supercontinuum generation speckle reduction optical coherence tomography 

摘      要：In most coherent imaging modality,speckle noise is a major cause that blurs the boundary of tissues and degrades the image contrast.By utilizing the unique properties of supercontinuum(SC)generated by noise-like pulses(NLPs)and a simple multi-frame averaging technique,we achieved significant speckle reduction in spectral domain optical coherence tomography(SD-OCT).We quantitatively compared the speckle of our proposed method with those of conventional swept source OCT(SS-OCT)and SD-OCT based on commercial light sources.The experimental results show that SC pumped by NLPs combined with noncoherent averaging method achieves better denoising performance in terms of contrast to noise ratio(CNR).