Role of mitophagy in the hallmarks of aging

作     者：Jie Wen Tingyu Pan Hongyan Li Haixia Fan Jinhua Liu Zhiyou Cai Bin Zhao 

作者机构：Department and Institute of NeurologyGuangdong Medical UniversityZhanjiangGuangdong 524001China Guangdong Key Laboratory of Aging-related Cardiac and Cerebral DiseasesZhanjiangGuangdong 524001China Chongqing Key Laboratory of Neurodegenerative DiseasesChongqing 400013China Department of NeurologyChongqing General HospitalChongqing 400013China Department of Neurologythe Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Chongqing Medical UniversityChongqing 400042China 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2023年第37卷第1期

页      面：1-14页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 

基　　金：supported by the Construction Project of Capacity Improvement Plan for Chongqing Municipal Health Commission affiliated unit (2019NLTS001)-ZS03174 the operating grant to Chongqing Key Laboratory of Neurodegenerative, and Diseases (Grant No. 1000013) Chongqing Talent Project (Grant No. 2000062)。 

主　　题：mitophagy aging dietary restriction telomere shortening epigenetic alterations protein imbalance 

摘      要：Aging, subjected to scientific scrutiny, is extensively defined as a time-dependent decline in functions that involves the majority of organisms. The time-dependent accretion of cellular lesions is generally a universal trigger of aging, while mitochondrial dysfunction is a sign of aging. Dysfunctional mitochondria are identified and removed by mitophagy, a selective form of macroautophagy. Increased mitochondrial damage resulting from reduced biogenesis and clearance may promote the aging process. The primary purpose of this paper is to illustrate in detail the effects of mitophagy on aging and emphasize the associations between mitophagy and other signs of aging, including dietary restriction, telomere shortening, epigenetic alterations, and protein imbalance.The evidence regarding the effects of these elements on aging is still limited. And although the understanding of relationship between mitophagy and aging has been long-awaited, to analyze details of such a relationship remains the main challenge in aging studies.