Peptide-Based AIEgens:From Molecular Design,Stimuli Responsiveness to Biomedical Application

作     者：Ben-Li Song Xue-Hao Zhang Zeng-Ying Qiao Hao Wang 

作者机构：School of Pharmaceutical SciencesHenan Institute of Advanced TechnologyZhengzhou UniversityHenan 450001 CAS Center for Excellence in NanoscienceCAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2022年第4卷第2期

页      面：437-455页

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Key R&D Program of China(no.2018YFE0205400) the National Natural Science Foundation of China(nos.51725302 and 31870998) the Strategic Priority Research Program of the Chinese Academy of Sciences(no.XDB36000000) the Beijing Nova Program of Science and Technology(no.Z191100001119091). 

主　　题：peptide AIEgens nanomaterials responsive bioimaging anticancer 

摘      要：Luminogens with aggregation-induced emission(AIEgens)have a wide range of biomedical applications in bioimaging,photodynamic anticancer,antibacterial therapy,and other fields,owing to their unique photophysical properties.The precise structural design and modification of AIE molecules have aroused great interest in the past years.As peptides-AIE hybrid materials,peptide-based AIEgens generally have better solubility,biocompatibility,and lower systemic toxicity.The functional diversity,modularity,and portability of peptides provide more possibilities for the intelligent structure and functional design of AIEgens.This review summarizes the recent research progress of peptide-based AIEgens nanomaterials,from molecular design,stimuli responsiveness to biomedical application,focusing on the advantages of peptides and AIE molecules as conjugates.Finally,a summary of the challenges and opportunities of peptide-based AIEgens nanomaterials for future clinical biomedical applications is presented.