Static superconducting gantry‑based proton CT combined with X‑ray CT as prior image for FLASH proton therapy

作     者：Yu‑Qing Yang Wen‑Cheng Fang Xiao‑Xia Huang Jian‑Hao Tan Cheng Wang Chao‑Peng Wang Zhen‑Tang Zhao Yu-Qing Yang;Wen-Cheng Fang;Xiao-Xia Huang;Jian-Hao Tan;Cheng Wang;Chao-Peng Wang;Zhen-Tang Zhao

作者机构：Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China University of Chinese Academy of SciencesBeijing 100049China School of Physical Science and TechnologyShanghaiTech UniversityShanghai 201210China Shanghai Synchrotron Radiation FacilityShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2023年第34卷第1期

页      面：125-135页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 1010[医学-医学技术（可授医学、理学学位）] 0804[工学-仪器科学与技术] 0703[理学-化学] 070202[理学-粒子物理与原子核物理] 0812[工学-计算机科学与技术（可授工学、理学学位）] 1009[医学-特种医学] 0702[理学-物理学] 

基　　金：supported by the Research collaboration on Thailand new synchrotron light source facility(SPS-Ⅱ)(No.ANSO-CRKP-2020-16) 

主　　题：Proton therapy Proton CT FLASH treatment Real-time image-guided radiotherapy 

摘      要：Proton FLASH therapy with an ultra-high dose rate is in urgent need of more accurate treatment plan system(TPS)to promote the development of proton computed tomography(CT)without intrinsic error compared with the transformation from X-ray *** paper presents an imaging mode of proton CT based on static superconducting gantry different from the conventional rotational *** beam energy for proton CT is fixed at 350 MeV,which is boosted by a compact proton linac from 230 MeV,and then delivered by the gantry to scan the patient’s body for proton *** study demonstrates that the static superconducting gantry-based proton CT is effective in clinical *** particular,the imaging mode,which combines the relative stopping power(RSP)map from X-ray CT as prior knowledge,can produce much a higher accuracy RSP map for TPSs and positioning and achieve ultra-fast image for real-time image-guided *** paper presents the conceptual design of a boosting linac,static superconducting gantry and proton CT imaging *** feasibility of energy enhancement is verified by simulation,and results from Geant4 simulations and reconstruction algorithms are presented,including the simulation verification of the advantage of the imaging mode.