Prevalence of maturity-onset diabetes of the young in phenotypic type 2 diabetes in young adults:a nationwide,multi-center,cross-sectional survey in China

作     者：Yan Chen Jing Zhao Xia Li Zhiguo Xie Gan Huang Xiang Yan Houde Zhou Li Zheng Tao Xu Kaixin Zhou Zhiguang Zhou 

作者机构：National Clinical Research Center for Metabolic DiseasesKey Laboratory of Diabetes Immunology(Central South University)Ministry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China College of Life SciencesThe University of Chinese Academy of SciencesBeijing 100049China National Laboratory of BiomacromoleculesCAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Shandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 271016China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第1期

页      面：56-64页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Science and Technology Innovation Program of Hunan Province(No.2020RC4044) National Science and Technology Infrastructure Program(No.2013BAI09B12) 

主　　题：Maturity-onset diabetes of the young Type 2 diabetes Young adults 

摘      要：Background:Maturity-onset diabetes of the young(MODY)is the most common monogenic *** aim of this study was to assess the prevalence of MODY in phenotypic type 2 diabetes(T2DM)among Chinese young ***:From April 2015 to October 2017,this cross-sectional study involved 2429 consecutive patients from 46 hospitals in China,newly diagnosed between 15 years and 45 years,with T2DM phenotype and negative for standardized glutamic acid decarboxylase antibody at the core *** using a custom monogenic diabetes gene panel was performed,and variants of 14 MODY genes were interpreted as per current ***:The survey determined 18 patients having genetic variants causing MODY(6 HNF1A,5 GCK,3 HNF4A,2 INS,1 PDX1,and 1 PAX4).The prevalence of MODY was 0.74%(95%confidence interval[CI]:0.40-1.08%).The clinical characteristics of MODY patients were not specific,72.2%(13/18)of them were diagnosed after 35 years,47.1%(8/17)had metabolic syndrome,and only 38.9%(7/18)had a family history of *** significant difference in manifestations except for hemoglobin A1c levels was found between MODY and non-MODY ***:The prevalence of MODY in young adults with phenotypic T2DM was 0.74%,among which HNF1A-,GCK-,and HNF4A-MODY were the most common *** features played a limited role in the recognition of MODY.