Endothelial cell metabolism in sepsis

作     者：Jue-xian Wei Hui-lin Jiang Xiao-hui Chen Jue-xian Wei;Hui-lin Jiang;Xiao-hui Chen

作者机构：Emergency Departmentthe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China 

出 版 物：《World Journal of Emergency Medicine》 (世界急诊医学杂志（英文）)

年 卷 期：2023年第14卷第1期

页      面：10-16页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82272236) Key Emergency Medical Disciplines and Specialities Program of Guangzhou(2021-2023)。 

主　　题：Sepsis Endothelium Metabolism Glycolysis Oxidative phosphorylation Fatty acid metabolism Amino acid metabolism 

摘      要：BACKGROUND:Endothelial dysfunction in sepsis is a pathophysiological feature of septic organ failure.Endothelial cells(ECs)exhibit specific metabolic traits and release metabolites to adapt to the septic state in the blood to maintain vascular homeostasis.METHODS:Web of Science and PubMed were searched from inception to October 1,2022.The search was limited to the English language only.Two reviewers independently identified studies related to EC metabolism in sepsis.The exclusion criteria were duplicate articles according to multiple search criteria.RESULTS:Sixty articles were included,and most of them were cell and animal studies.These studies reported the role of glycolysis,oxidative phosphorylation,fatty acid metabolism,and amino acid metabolism in EC homeostasis.including glycolysis,oxidative phosphorylation,fatty acid metabolism and amino acid metabolism.However,dysregulation of EC metabolism can contribute to sepsis progression.CONCLUSION:There are few clinical studies on EC metabolism in sepsis.Related research mainly focuses on basic research,but some scientific problems have also been clarified.Therefore,this review may provide an overall comprehension and novel aspects of EC metabolism in sepsis.