Augmentation of transforming growth factor-βsignaling for the treatment of neurological disorders

作     者：Jian Luo Jian Luo

作者机构：Palo Alto Veterans Institute for ResearchVA Palo Alto Health Care SystemPalo AltoCAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第8期

页      面：1711-1712页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by NIH Nos.R01NS092868 and RF1AG059694(both to JL) 

主　　题：neurological disorders inflammation 

摘      要：Members of the transforming growth factor-β(TGF-β)superfamily perform a wide range of essential functions during development and in adulthood,as well as in response to injury and inflammation(Luo,2022).In the adult central nervous system,TGF-βs and their receptors are widely expressed in all of the major neuronal,glial,and vascular cell *** of the TGF-βsuperfamily are pivotal responders to pathological insults to the *** of TGF-βsignaling contributes to pathogenesis of neurological *** of TGF-βsignaling pathway alters pathological and functional outcomes in models of neurological diseases(Luo,2022).Therefore,the TGF-βsignaling pathway has emerged as a potential therapeutic target against neurological diseases.