Mitochondrial dynamics caused by QoIs and SDHIs fungicides depended on FgDnm1 in Fusarium graminearum

作     者：KANG Jin-bo ZHANG Jie LIU Yin-kai SONG Ji-chang OU Jian-lin TAO Xian ZHOU Ming-guo DUAN Ya-bing KANG Jin-bo;ZHANG Jie;LIU Yin-kai;SONG Ji-chang;OU Jian-lin;TAO Xian;ZHOU Ming-guo;DUAN Ya-bing

作者机构：College of Plant ProtectionNanjing Agricultural UniversityNanjing 210095P.R.China 

出 版 物：《Journal of Integrative Agriculture》 (农业科学学报（英文版）)

年 卷 期：2023年第22卷第2期

页      面：481-494页

核心收录：

学科分类：09[农学] 0904[农学-植物保护] 090401[农学-植物病理学] 090402[农学-农业昆虫与害虫防治] 

基　　金：supported by the National Natural Science Foundation of China (31772190) the Jiangsu Agriculture Science and Technology Innovation Fund, China (JASTIF) (CX(21)2037) the Postgraduate Research & Practice Innovation Program of Jiangsu Province, China (KYCX21_0631) 

主　　题：Fusarium graminearum FgDnm1 mitochondrial dynamics fungicides 

摘      要：Fusarium head blight(FHB) caused by Fusarium graminearum is a devastating fungal disease on small grain cereal crops,because it reduces yield and quality and causes the mycotoxin contamination to the *** and dynamin-related proteins(DRPs) are large GTPase superfamily members,which are typically involved in the budding and division of vesicles in eukaryotic cells,but their roles in Fusarium *** ***,we found that FgDnm1,a DRP and homolog to Dnm1 in Saccharomyces cerevisiae,contributes to the normal fungal growth,sexual reproduction and sensitivity to *** addition,we found FgDnm1 co-localizes with mitochondria and is involved in toxisome formation and deoxynivalenol(DON) *** quinone outside inhibitors(QoIs) and succinate dehydrogenase inhibitors(SDHIs) cause fragmentated morphology of ***,the deletion of FgDnm1displays filamentous mitochondria and blocks the mitochondrial fragmentation induced by QoIs and *** together,our studies uncover the effect of mitochondrial dynamics in fungal normal growth and how such events link to fungicides sensitivity and toxisome ***,we concluded that altered mitochondrial morphology induced by QoIs and SDHIs depends on FgDnm1.