Efficient antibody evasion but reduced ACE2 binding by the emerging SARS-CoV-2 variant B.1.640.2

作     者：Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Sebastian Schulz Anne Cossmann Alexandra Dopfer-Jablonka Martin S.Winkler Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann 

作者机构：Infection Biology UnitGerman Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and PsychologyGeorg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Division of Molecular ImmunologyDepartment of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054ErlangenGermany Department for Rheumatology and ImmunologyHannover Medical SchoolCarl-Neuberg-Straße 130625HannoverGermany German Centre for Infection Research(DZIF)Partner Site Hannover-BraunschweigHannoverGermany Centre for Individualised Infection Medicine(CiiM)HannoverGermany Department of AnesthesiologyUniversity of Göttingen Medical CenterGöttingenGeorg-August University of GöttingenRobert-Koch-Straße 4037075GöttingenGermany 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2022年第19卷第9期

页      面：1067-1069页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：SP acknowledges funding from BMBF(01KI2006D,01KI20328A,01KI20396,01KX2021) the Ministry for Science and Culture of Lower Saxony(14-76103-184,MWK HZI COVID-19) the German Research Foundation(DFG,PO 716/11-1,PO 716/14-1) MSW received unrestricted funding from Sartorius AG,Lung Research.H-MJ received funding from BMBF(01KI2043,NaFoUniMedCovid19-COVIM:01KX2021) Bavarian State Ministry for Science and the Arts and Deutsche Forschungsgemeinschaft(DFG)through the research training groups RTG1660 and TRR130.GMNB acknowledges funding from the German Center for Infection Research(grant no 80018019238). 

主　　题：ACE2 harbor neutral 

摘      要：The SARS-CoV-2 spike(S)protein engages ACE2 for cell entry,and the S protein/ACE2 interface is an important target for neutralizing antibodies.In the course of the COVID-19 pandemic,SARS-CoV-2 variants have emerged that harbor mutations in the S protein,which confer neutralization resistance and allow viral spread in immunologically nonnaive populations.The most prominent example is the highly mutated Omicron variant,which infects convalescent or vaccinated individuals with unprecedented efficiency[1,2].