Redox regulation of the immune response
作者机构：Deakin UniversityIMPACT-the Institute for Mental and Physical Health and Clinical TranslationSchool of MedicineBarwon HealthGeelongVICAustralia Department of Medical BiologyMedical University-PlovdivPlovdivBulgaria Research Institute at Medical University-PlovdivPlovdivBulgaria Department of PsychiatryFaculty of MedicineKing Chulalongkorn Memorial HospitalBangkokThailand Department of PsychiatryMedical University of PlovdivPlovdivBulgaria
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2022年第19卷第10期
页 面：1079-1101页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
主 题：Oxidative and nitrosative stress Immune response Inflammation Antioxidants Physiological stres
摘 要：The immune-inflammatory response is associated with increased nitro-oxidative *** aim of this mechanistic review is to examine:(a)the role of redox-sensitive transcription factors and enzymes,ROS/RNS production,and the activity of cellular antioxidants in the activation and performance of macrophages,dendritic cells,neutrophils,T-cells,B-cells,and natural killer cells;(b)the involvement of high-density lipoprotein(HDL),apolipoprotein A1(ApoA1),paraoxonase-1(PON1),and oxidized phospholipids in regulating the immune response;and(c)the detrimental effects of hypernitrosylation and chronic nitro-oxidative stress on the immune *** redox changes during immune-inflammatory responses are orchestrated by the actions of nuclear factor-κB,HIF1α,the mechanistic target of rapamycin,the phosphatidylinositol 3-kinase/protein kinase B signaling pathway,mitogen-activated protein kinases,5 AMP-activated protein kinase,and peroxisome proliferator-activated *** performance and survival of individual immune cells is under redox control and depends on intracellular and extracellular levels of ROS/*** are heavily influenced by cellular antioxidants including the glutathione and thioredoxin systems,nuclear factor erythroid 2-related factor 2,and the HDL/ApoA1/PON1 *** nitro-oxidative stress and hypernitrosylation inhibit the activity of those antioxidant systems,the tricarboxylic acid cycle,mitochondrial functions,and the metabolism of immune *** conclusion,redox-associated mechanisms modulate metabolic reprogramming of immune cells,macrophage and T helper cell polarization,phagocytosis,production of pro-versus anti-inflammatory cytokines,immune training and tolerance,chemotaxis,pathogen sensing,antiviral and antibacterial effects,Toll-like receptor activity,and endotoxin tolerance.
维普期刊数据库