Phytochemical analysis and inhibitory effects of Calligonum polygonoides on pancreatic α-amylase and β-glucosidase enzymes

作     者：Mushtaq Ahmed Naila Sher Nadia Mushtaq Rahmat Ali Khan Mushtaq Ahmed;Naila Sher;Nadia Mushtaq;Rahmat Ali Khan

作者机构：Department of BiotechnologyFaculty of Biological SciencesUniversity of Science&TechnologyBannu 28100KPK-Pakistan Department of BotanyFaculty of Biological SciencesUniversity of Science&TechnologyBannu 28100KPKPakistan 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2022年第42卷第3期

页      面：426-431页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

主　　题：Calligonum polygonoides phytochemicals alpha-amylases beta-glucosidase 

摘      要：OBJECTIVES:To estimate the existence of phytochemicals and then to determine the antidiabetic activity againstα-amylase andβ-glucosidase inhibition in vitro.METHODS:The study was carried out by following standard procedures.RESULTS:Phytochemicals analysis indicated the presence of different phytochemicals.The total phenolic content was 6.055 mg GAE/g and the total flavonoid content was 5.706 mg RU/g in the plant extract.The total saponins,alkaloids,and tannins contents were(0.044%),(2.88%)and(2.862 nm)respectively.α-amylase inhibition activity of Calligonum polygonoides(CP)extract was 70%with IC50 of 610μg/mL and that ofβ-glucosidase inhibition activity was 65%with IC50 of 640μg/mL.CONCLUSION:The findings reported for the first time the antidiabetes-promoting effects of an extract of CP in vitro,thus validating their promising anti-diabetes potential.