Lag time,high-risk histopathological features,metastasis,and survival interrelation in retinoblastoma:a perspective from lower-middle income country

作     者：Purjanto Tepo Utomo Datu Respatika Bambang Ardianto Hanggoro Tri Rinonce Didik Setyo Heriyanto Banu Aji Dibyasakti Irene Titin Darajati Indra Tri Mahayana Agus Supartoto 

作者机构：Department of OphthalmologyFaculty of Medicine Public Health and NursingUniversitas Gadjah Mada-Prof.Dr.Sardjito General HospitalYogyakarta 55281Indonesia Department of Child HealthFaculty of Medicine Public Health and NursingUniversitas Gadjah Mada-Prof.Dr.Sardjito General HospitalYogyakarta 55281Indonesia Department of Anatomical PathologyFaculty of Medicine Public Health and NursingUniversitas Gadjah Mada-Prof.Dr.Sardjito General HospitalYogyakarta 55281Indonesia 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2022年第15卷第12期

页      面：1994-2000页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported in part by funding from the the Teuku Jacobs Foundation Research Fellowship Program(No.#312) 

主　　题：retinoblastoma lag time metastasis survival staging laterality 

摘      要：AIM:To investigate the impact of lag time to metastasis and survival rates among patients with ***:This retrospective study was conducted with 52 patients from the Department of Ophthalmology and the Department of Pediatrics of *** General Hospital,between 1^(st) January 2014 and 31^(st) December *** time was defined as the time delay between the first sign of retinoblastoma to the diagnosis of *** subjects with lag timeone year were included in the case group,while the subjects with lag timeone year were included in the control ***:The lag time was significantly correlated with American Joint Committee on Cancer and Intraocular Classification of Retinoblastoma staging of retinoblastoma(P=0.005 and P=0.006,respectively).The lag time was also significantly correlated with both metastasis event[odds ratio(OR):5.06,95%Cl:1.56-16.44,P=0.006]and mortality(OR:4.54,95%Cl:1.37-15.07,P=0.011).The follow-up was continued for 32 subjects for 3y after initial *** analysis revealed a significant difference among these two groups(P=0.021).Furthermore,lag time was significantly correlated with survival of retinoblastoma(r=-0.53,P=0.046).CONCLUSION:The study highlights the importance of lag time between the onset of first symptoms and the time of retinoblastoma diagnosis which significantly contribute to metastasis and mortality of patients with *** for the early detection of retinoblastoma should be performed for individuals at-risk to minimize lag time and improve the outcomes.