Intratumoral bacteria interact with metabolites and genetic alterations in hepatocellular carcinoma

作     者：Chen Xue Junjun Jia Xinyu Gu Lin Zhou Juan Lu Qiuxian Zheng Yuanshuai Su Shusen Zheng Lanjuan Li 

作者机构：State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Division of Hepatobiliary and Pancreatic SurgeryDepartment of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第10期

页      面：3662-3664页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by the National Key Research and Development Program of China(81790631) the National Nature Science Foundation of China(U20A20343) Zhejiang University Academic Award for Outstanding Doctoral Candidates(2020055)。 

主　　题：alterations diagnosis cancer 

摘      要：Dear Editor,Hepatocellular carcinoma(HCC),which ranks globally as the third leading cause of cancer-related deaths,is highly prevalent,and most patients are diagnosed with advanced-stage cancer when treatments are largely ineffective.1 Thus,there is an urgent need for earlier diagnosis to improve HCC patient outcomes.Although many types of tumors have intratumor bacteria,the tumor microbiome is poorly characterized because of limitations in the technology for detection.Recently,Nejman et al.