Single-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer
作者机构：Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation OncologyShandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China Research Unit of Radiation OncologyChinese Academy of Medical SciencesJinan 250117China Department of NephrologyFirst Medical Center of Chinese PLA General HospitalBeijing 100853China Department of OncologyRenmin Hospital of Wuhan UniversityWuhan 430060China School of Clinical MedicineWeifang Medical UniversityWeifang 261053China Department of Gynecologic OncologyShandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China Department of Radiation OncologyFifth Medical Center of Chinese PLA General HospitalBeijing 100071China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第2期
页 面：827-841页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This study was supported by funds from the National Natural Science Foundation of China(82030082 and 81871895) the Academic Promotion Program of Shandong First Medical University(2019ZL002) Key Research and Development Project of Shandong Province of China(2021CXGC011102) the Radiation Oncology Innovate Unit,Chinese Academy of Medical Sciences(2019RU071) Young Taishan Scholars and Academic Promotion Program of Shandong First Medical University(2019RC003) Shandong Provincial Natural Science Foundation(ZR2021QH006) Beijing Bethune Charitable Foundation(flzh202118)
主 题：cervical chemotherapy immunity
摘 要：Radiochemotherapy(RCT)is a powerful treatment for cervical cancer,which affects not only malignant cells but also the immune and stromal compartments of the *** the remodeling of the local ecosystem induced by RCT would provide valuable insights into improving treatment strategies for cervical *** this study,we applied single-cell RNA-sequencing to paired pre-and post-RCT tumor biopsies from patients with cervical cancer and adjacent normal cervical *** found that the residual population of epithelial cells post-RCT showed upregulated expression of MHC class II ***,RCT led to the accumulation of monocytic myeloid-derived suppressor cells with increased pro-inflammatory features and CD16+NK cells with a higher cytotoxic gene expression ***,subclusters of T cells showed no significant increase in the expression of cytotoxic features *** results reveal the complex responses of the tumor ecosystem to RCT,providing evidence of activation of innate immunity and MHC-II upregulation in cervical cancer.
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