Functionality of dietary antimicrobial peptides in aquatic animal health:Multiple meta-analyses

作     者：Jinhai Wang Alan E.Wilson Baofeng Su Rex A.Dunham Jinhai Wang;Alan E.Wilson;Baofeng Su;Rex A.Dunham

作者机构：School of FisheriesAquaculture and Aquatic SciencesAuburn University203 Swingle HallAuburnAL 36849USA 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2023年第12卷第1期

页      面：200-214页

核心收录：

学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 0906[农学-兽医学] 09[农学] 

基　　金：supported by a scholarship from the China Scholarship Council 

主　　题：Fish AMP Oral administration Feed additive Dose-effect Immune 

摘      要：Effects of antimicrobial peptides(AMP)added to diets on aquatic animal health and body function are influenced by multiple factors such as animal species,initial body weight,the dosage of AMP and feeding ***,there is limited knowledge on the relationship between these factors and the body function of aquatic ***,we aimed to perform multiple meta-analyses to investigate the effects of dietary AMP on growth performance(feed conversion ratio[FCR],specific growth rate[SGR]),enzyme activity(superoxide dismutase activity[SOD],lysozyme activity[LSA]),disease resistance(cumulative survival rate[CSR],the expression of immune-related genes[GENE])and the abundance of gut microbiota(MICRO)from a pool of empirical ***,the dose-effect model was applied to determine the optimal AMP dose,initial body weight and feeding duration to maximize body *** conduct the meta-analyses,we included 34 publications that estimated 705 effect sizes across 21 fish,2 shrimp and 2 shellfish *** results confirmed that the inclusion of AMP in the diet can significantly improve SGR,SOD,LSA,CSR and GENE and decrease FCR for aquatic ***,our findings implied a slight positive effect of AMP on MICRO albeit with a limited number of studies available on fish gut microbial *** no significant linear or quadratic relationship was predicted by meta-regression,the dose-effect indicated that the optimal AMP doses for FCR,SGR,SOD and LSA were 707.5,750.0,1,050.0 and 937.5 mg/kg,*** together,fish with an initial body weight of 30 g could be fed with a dose of 600 to 800 mg/kg for 2 mo when AMP-supplemented diets were applied in aquaculture,which can effectively improve body function and health while lowering aquafeed *** addition,more studies should address fish gut microbiota to delimitate the influence of dietary AMP on MICRO in the future.