Liver injury in COVID-19: Clinical features, potential mechanisms, risk factors and clinical treatments

作     者：Shu-Wu Zhao Yi-Ming Li Yi-Lin Li Chen Su 

作者机构：Department of AnesthesiologyHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineChangsha 410013Hunan ProvinceChina School of Basic Medical ScienceNaval Medical University/Second Military UniversityShanghai 200433China Department of PathologyHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineChangsha 410013Hunan ProvinceChina Department of Anesthesiology and PainHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineChangsha 410013Hunan ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第2期

页      面：241-256页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China,No.81901141 the Scientific Research Project of Hunan Provincial Health Commission,No.202204114480 

主　　题：Liver injury COVID-19 Clinical feature Risk factor Treatment and management strategy 

摘      要：The coronavirus disease 2019(COVID-19)pandemic has been a serious threat to global health for nearly 3 *** addition to pulmonary complications,liver injury is not uncommon in patients with novel *** the prevalence of liver injury varies widely among COVID-19 patients,its incidence is significantly increased in severe ***,there is an urgent need to understand liver injury caused by *** features of liver injury include detectable liver function abnormalities and liver imaging *** function tests,computed tomography scans,and ultrasound can help evaluate liver *** factors for liver injury in patients with COVID-19 include male sex,preexisting liver disease including liver transplantation and chronic liver disease,diabetes,obesity,and *** date,the mechanism of COVID-19-related liver injury is not fully *** pathophysiological basis can generally be explained by systemic inflammatory response,hypoxic damage,ischemia-reperfusion injury,and drug side *** this review,we systematically summarize the existing literature on liver injury caused by COVID-19,including clinical features,underlying mechanisms,and potential risk ***,we discuss clinical management and provide recommendations for the care of patients with liver injury.