Role of advanced imaging techniques in the evaluation of oncological therapies in patients with colorectal liver metastases
作者机构：Department of Advanced Biomedical SciencesUniversity of Naples"Federico II"Napoli 80131Italy Institute of Biostructures and BioimagingNational Research CouncilNapoli 80131Italy
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2023年第29卷第3期
页 面：521-535页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Colorectal cancer metastases Prediction response Computed tomography Magnetic resonance imaging Positron emission tomography Parametric imaging
摘 要：In patients with colorectal liver metastasis(CRLMs)unsuitable for surgery,oncological treatments,such as chemotherapy and targeted agents,can be ***-sectional imaging[computed tomography(CT),magnetic resonance imaging(MRI),18-fluorodexoyglucose positron emission tomography with CT/MRI]evaluates the response of CRLMs to therapy,using post-treatment lesion shrinkage as a qualitative imaging *** point is critical because the risk of toxicity induced by oncological treatments is not always balanced by an effective response to ***,there is a pressing need to define biomarkers that can predict treatment responses and estimate the likelihood of drug resistance in individual *** quantitative imaging(diffusionweighted imaging,perfusion imaging,molecular imaging)allows the in vivo evaluation of specific biological tissue features described as quantitative ***,radiomics can represent large amounts of numerical and statistical information buried inside cross-sectional images as quantitative *** a result,parametric analysis(PA)translates the numerical data contained in the voxels of each image into quantitative parameters representative of peculiar neoplastic features such as perfusion,structural heterogeneity,cellularity,oxygenation,and glucose *** could be a potentially useful imaging marker for predicting CRLMs treatment *** review describes the role of PA applied to cross-sectional imaging in predicting the response to oncological therapies in patients with CRLMs.
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