Effect of Quercetin on Formation of Choroidal Neovascularization (CNV) in Age-related Macular Degeneration (AMD)

作     者：George C.Y. Chiou 

作者机构：Institute of Ocular PharmacologyCollege of MedicineTexas A&M Health Science CenterCollege StationTX 77843USA 

出 版 物：《Eye Science》 (眼科学报（英文版）)

年 卷 期：2011年第26卷第1期

页      面：23-29页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：槲皮素 年龄相关 新生血管 AMD 脉络膜 变性 黄斑 氧化应激损伤 

摘      要：Purpose:Age-related macular degeneration(AMD)as a disease entity is dry at early stage and made up of two main components at late stage:atrophic AMD and exudative *** acts as an anti-oxidant to protect retinal pigment epithelial cells(RPE)from damaged by oxidative stress,but its effect on formation of choroidal neovascularization(CNV)in AMD is *** aim of this study is to investigate the effect of quercetin on the formation of CNV in ***:The development of CNV induced by laser was *** fluorescein angiography(FA).Colored microsphere technique was used to determine the choroidal blood flow in ocular hypertensive rabbit *** in vitro studies,HUVECs were treated with NaIO3,H2O2 and NaN3 to induce oxidative cell *** effect of quercetin on various oxidations-induced injuries in HUVECs was measured by MTT *** migration was assessed using a wound healing ***:Quercetin significantly inhibited the formation of laser-induced *** choroidal blood flow in rabbit eyes was significantly increased after quercetin *** vitro results showed quercetin enhanced various oxidations-induced injuries in HUVECs and inhibited migration of HUVECs during wound ***:Quercetin inhibited the formation of CNV both in vivo and in vitro and increased choroidal blood *** could become a promising candidate for the treatment of AMD.