Modulation of type I interferon signaling by natural products in the treatment of immune-related diseases
作者机构：School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China School of Life SciencesBeijing University of Chinese MedicineBeijing 102488China
出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)
年 卷 期：2023年第21卷第1期
页 面：3-18页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：This work was supported by Beijing Nova Program of Science&Technology(Nos.Z201100006820025 and Z211100002121167) the Young Elite Scientists Sponsorship Program from CACM(No.CACM-2020-QNRC2-04) the National Natural Science Foundation of China(No.82004029)
主 题：Type I interferons Natural products Infection Cancer Autoimmune diseases
摘 要：Type I interferon(IFN)is considered as a bridge between innate and adaptive *** activation or inhibition of type I IFN signaling is essential for host defense against pathogen invasion,tumor cell proliferation,and overactive immune *** to intricate and diverse chemical structures,natural products and their derivatives have become an invaluable source inspiring innovative drug *** addition,some natural products have been applied in clinical practice for infection,cancer,and autoimmunity over thousands of years and their promising curative effects and safety have been ***,whether these natural products are primarily targeting type I IFN signaling and specific molecular targets involved are not fully *** the current review,we thoroughly summarize recent advances in the pharmacology researches of natural products for their type I IFN activity,including both agonism/activation and antagonism/inhibition,and their potential application as ***,the source and chemical nature of natural products with type I IFN activity are highlighted and their specific molecular targets in the type I IFN pathway and mode of action are *** conclusion,natural products possessing type I IFN activity represent promising therapeutic strategies and have a bright prospect in the treatment of infection,cancer,and autoimmune diseases.
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