免疫和炎性疾病的低剂量白介素-2治疗:临床应用和前景
Low-dose interleukin-2 therapy in autoimmune and inflammatory diseases:facts and hopes作者机构:Department of Rheumatology and ImmunologyBeijing Key Laboratory for Rheumatism and Immune DiagnosisPeking University People's HospitalBeijing 100044China Peking-Tsinghua Center for Life SciencesBeijing 100871China
出 版 物:《Science Bulletin》 (科学通报(英文版))
年 卷 期:2023年第68卷第1期
页 面:10-13页
核心收录:
学科分类:1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金:supported by the National Natural Science Foundation of China(32141004 and U1903210) Macao Science and Technology Fund(0094/2018/A3) Beijing Science and Technology Program(Z191100006619114)
摘 要:Autoimmune diseases(AIDs)are characterized by impaired function of regulatory T(Treg)cells and excessive activation of effector T(Teff)*** agents and corticosteroids have long been the cornerstone of treatment for these ***,these medications may cause life-threatening infections and other severe adverse *** resolve this dilemma,safe and more effective therapeutic approaches are urgently needed.