Super enhancers:Pathogenic roles and potential therapeutic targets for acute myeloid leukemia(AML)

作     者：Ziyang Cao Yi Shu Jinxia Wang Chunxia Wang Tienan Feng Li Yang Jingbo Shao Lin Zou 

作者机构：Clinical Research UnitShanghai Children’s HospitalShanghai Jiao Tong UniversityShanghai 200062PR China Institute of Pediatric InfectionImmunityCritical Care MedicineShanghai Jiao Tong University School of MedicineShanghai 200062PR China Center for Clinical Molecular Laboratory Medicine of Children’s Hospital of Chongqing Medical UniversityChongqing 400014PR China Clinical Research InstituteShanghai Jiao Tong University School of MedicineShanghai 200025PR China Department of HematologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Hematology/OncologyShanghai Children’s HospitalShanghai Jiao Tong UniversityShanghai 200062PR China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2022年第9卷第6期

页      面：1466-1477页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was partially supported by the Natural Science Foundation of China(No.82070167 81870126 and 81802803). 

主　　题：Classification Leukemogenesis Super enhancer Therapy targets 

摘      要：Acute myeloid leukemia(AML)is a malignant hematological tumor with disordered oncogenes/tumor suppressor genes and limited treatments.The potent anti-cancer effects of bromodomain and extra-terminal domain(BET)inhibitors,targeting the key component of super enhancers,in early clinical trials on AML patients,implies the critical role of super enhancers in AML.Here,we review the concept and characteristic of super enhancer,and then summarize the current researches about super enhancers in AML pathogenesis,diagnosis and classification,followed by illustrate the potential super enhancer-related targets and drugs,and propose the future directions of super enhancers in AML.This information provides integrated insight into the roles of super enhancers in this disease.