IMMUNOCYTOCHEMICAL ANALYSIS OF ras RELATED PROTEINS WITH ANTISERUM AGAINST PEPTIDE FRAGMENT OF ras ONCOPROTEIN P21 (56—66) IN HUMAN CANCER TISSUES

作     者：张红 陈韵能 钮经义 李士谔 林原 刘彤华 ZHANG HONG CHEN YUN-NENG, NIU JING-YI(Shanghai Institute of Biochemistry, Academia Sinica) LI SHI-E LIN YUAN LIU TONG-HUA(Beijing Union Medical College Hospital and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences)

作者机构：Shanghai Institute of Biochemistry Academia Sinica Beijing Union Medical College Hospital and Institute of Basic Medical Sciences Chinese Academy of Medical Sciences 

出 版 物：《Chinese Science Bulletin》 (科学通报(英文版))

年 卷 期：1989年第34卷第12期

页      面：1049-1053页

核心收录：

学科分类：07[理学] 08[工学] 

主　　题：ras oncoprotein P21 immunocytochemical analysis human primary cancer adjacent tissue. 

摘      要：The c-ras and its product P21 have been shown to play an important role in the initiation and development of some malignancies. The activation of c-ras may be associated with two mechanisms: (ⅰ) a point mutation of the codon at position 12 or 61 of the genome leading to a single amino acid alteration in the corresponding product P21; (ⅱ) enhanced expression of ras family encode proteins with