Current opinion on the regulation of small intestinal magnesium absorption

作     者：Siriporn Chamniansawat Nasisorn Suksridechacin Narongrit Thongon 

作者机构：Division of AnatomyDepartment of Medical SciencesFaculty of Allied Health SciencesBurapha UniversityMuang 20131ChonburiThailand Biodiversity Research CentreThailand Institute of Scientific and Technological ResearchKhlong Luang 12120Pathum ThaniThailand Division of PhysiologyDepartment of Medical SciencesFaculty of Allied Health SciencesBurapha UniversityMuang 20131ChonburiThailand 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第2期

页      面：332-342页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Hormone Magnesium absorption Paneth cells Proton pump inhibitor Regulation Small intestine 

摘      要：Magnesium(Mg^(2+))has an important role in numerous biological functions,and Mg^(2+)deficiency is associated with several ***,adequate intestinal absorption of Mg^(2+)is vital for *** small intestine was previously thought to absorb digested Mg^(2+)exclusively through an unregulated paracellular mechanism,which is responsible for approximately 90%of total Mg^(2+)*** studies,however,have revealed that the duodenum,jejunum,and ileum absorb Mg^(2+)through both transcellular and paracellular *** regulatory factors of small intestinal Mg^(2+)uptake also have been explored,e.g.,parathyroid hormone,fibroblast growth factor-23,apical acidity,proton pump inhibitor,and pH-sensing channel and *** mechanistic factors underlying proton pump inhibitor suppression of small intestinal Mg^(2+),such as magnesiotropic protein dysfunction,higher mucosal bicarbonate secretion,Paneth cell dysfunction,and intestinal inflammation,are currently being *** potential role of small intestinal microbiomes in Mg^(2+)absorption has also been *** this article,we reviewed the current knowledge on the mechanisms and regulatory factors of small intestinal Mg^(2+)absorption.