Reactive glia-to-GABAergic neuron reprogramming:a“golden touch”strategy to alleviate intractable seizures

作     者：Junzi Chen Zhongxia Li Liying Chen 

作者机构：The First School of Clinical MedicineKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang ProvinceCollege of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of PharmacySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310020China 

出 版 物：《Acta Epileptologica》 (癫痫学报（英文）)

年 卷 期：2022年第5卷第3期

页      面：213-216页

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：The work was funded by grant from the Natural Science Foundation of Zhejiang Province(Q22H309365) 

主　　题：seizures epilepsy programming 

摘      要：This commentary highlights a research article published recently in Cell Stem Cell“Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy.Generally,Lentini et *** a strategy to fulfill in vivo glia-to-neuron reprogramming,which is a potential disease-modifying strategy for treatment of intractable ***,we describe exciting research advances in the treatment of intractable seizures based on this research article,summarizing its key findings,emphasizing its importance and providing further ***,issues worthy of further investigations are also postulated so that clinic translation can be better achieved.