Salivary secretion impairment after preoperative irradiation and surgery in patients with oral squamous cell carcinoma

作     者：Ryoji Yoshida Hideki Nakayama Masashi Nagata Akimitsu Hiraki Kazutoshi Ota Masanori Shinohara 

作者机构：Department of Oral & Maxillofacial Surgery Sensory and MotorOrgan Sciences Faculty of Medical and PharmaceuticalSciences Kumamoto University Japan 

出 版 物：《中国口腔颌面外科杂志》 (China Journal of Oral and Maxillofacial Surgery)

年 卷 期：2008年第6卷第B5期

页      面：112-113页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：口腔癌 鳞状细胞癌 唾液腺 临床分析 

摘      要：Purpose: This study was designed to determine the influence of preoperative irradiation and surgical operation on salivary secretion impairment in patients with oral squamous cell carcinoma (OSCC)。Methods: A total of 42 patients with OSCC were studied between 2004 and 2008。Salivary secretion was evaluated by Saxson s test before and 3-4 weeks after preoperative 30 Gy of irradiation, and at various intervals after surgery。Results: After preoperative irradiation, salivary secretion was 40.8% compared with pretreatment salivary secretion, then 27.8% 6 months after surgery。In several patients whose data we can get by Saxson s test more than 6 months after surgery, salivary secretion markedly increased between 12 and 24 months after surgery。Conclusions: In-patient with OSCC received preoperative irradiation and surgery, salivary secretion was about 30% 6 months after operation, then likely to recover significantly between 12 and 24 months after surgery。