Peripheral and central control of obesity by primary cilia

作     者：Yue Wu Jun Zhou Yunfan Yang Yue Wu;Jun Zhou;Yunfan Yang

作者机构：Center for Cell Structure and FunctionShandong Provincial Key Laboratory of Animal Resistance BiologyCollaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinanShandong 250014China State Key Laboratory of Medicinal Chemical BiologyHaihe Laboratory of Cell EcosystemCollege of Life SciencesNankai UniversityTianjin 300071China Department of Cell BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong 250012China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2023年第50卷第5期

页      面：295-304页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(32100948,32100614,31991193) Natural Science Foundation of Shandong Province(ZR2021QC069). 

主　　题：Ciliopathy Metabolism Adipose tissue Adipogenesis Hypothalamus 

摘      要：Primary cilia are hair-like structures that protrude from the cell surface.They are capable of sensing external cues and conveying a vast array of signals into cells to regulate a variety of physiological activities.Mutations in cilium-associated genes are linked to a group of diseases with overlapping clinical manifestations,collectively known as ciliopathies.A significant proportion of human ciliopathy cases are accompanied by metabolic disorders such as obesity and type 2 diabetes.Nevertheless,the mechanisms through which dysfunction of primary cilia contributes to obesity are complex.In this review,we present an overview of primary cilia and highlight obesity-related ciliopathies.We also discuss the potential role of primary cilia in peripheral organs,with a focus on adipose tissues.In addition,we emphasize the significance of primary cilia in the central regulation of obesity,especially the involvement of ciliary signaling in the hypothalamic control of feeding behavior.This review therefore proposes a framework of both peripheral and central regulation of obesity by primary cilia,which may benefit further exploration of the ciliary role in metabolic regulation.