Therapeutic potential for targeting Annexin A1 in fibrotic diseases
作者机构：Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and BiomedicineCollege of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhouZhejiang 310018PR China Department of OncologyNo.903 Hospital of PLA Joint Logistic Support ForceXi Hu Affiliated Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310013PR China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2022年第9卷第6期
页 面：1493-1505页
核心收录：
学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(No.81770176) the Special Support Plan for Zhejiang Province High-level Talents(No.2019R52011) the Zhejiang Provincial Natural Science Foundation of China(No.LD22H310004) the Scientific Research Foundation of Zhejiang Sci-Tech University(No.21042100-Y).
主 题：Annexin A1 Anti-inflammatory Fibrosis Fibrotic diseases Sequence alignment
摘 要：Annexin A1,a well-known endogenous anti-inflammatory mediator,plays a critical role in a variety of pathological processes.Fibrosis is described by a failure of tissue regeneration and contributes to the development of many diseases.Accumulating evidence supports that Annexin A1 participates in the progression of tissue fibrosis.However,the fundamental mechanisms by which Annexin A1 regulates fibrosis remain elusive,and even the functions of Annexin A1 in fibrotic diseases are still paradoxical.This review focuses on the roles of Annexin A1 in the development of fibrosis of lung,liver,heart,and other tissues,with emphasis on the therapy potential of Annexin A1 in fibrosis,and presents future research interests and directions in fibrotic diseases.
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