Vitamin D receptor polymorphism and prostate cancer prognosis

作     者：Ahmed Z.El-attar Samia Hussein Mariam F.A.Salama Hanaa M.Ibrahim Amira S.AIKaramany Mansour K.Elsawi Mohamed Hemeda Ahmed Algazeery Ahmed Z.El-attar;Samia Hussein;Mariam F.A.Salama;Hanaa M.Ibrahim;Amira S.AIKaramany;Mansour K.Elsawi;Mohamed Hemeda;Ahmed Algazeery

作者机构：Oncology DepartmentFaculty of MedicineZagazig UniversityZagazigEgypt Medical Biochemistry and Molecular Biology DepartmentFaculty of MedicineZagazig UniversityZagazig44511Egypt Zoology DepartmentFaculty of SciencesZagazig UniversityZagazigEgypt Pathology DepartmentFaculty of MedicineZagazig UniversityZagazigEgypt Chemical Pathology DepartmentCairo University HospitalsCairoEgypt Urology DepartmentAl Ahrar Teaching HospitalZagazigEgypt 

出 版 物：《Current Urology》 (当代泌尿学（英文）)

年 卷 期：2022年第16卷第4期

页      面：246-255页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Prostate cancer Prostate-specific antigen Vitamin D receptor polymorphism 

摘      要：Background:Prostatic epithelial cells synthesize the active form of vitamin D(1,25-dihydroxyvitamin D3),which participates in regulating prostate ***,a synthetic form of vitamin D3,exhibits antiproliferative and prodifferentiation activities in prostate *** function of 1,25-dihydroxyvitamin D3 is mediated by its binding to vitamin D receptor(VDR).VDR forms a heterodimer,typically with retinoid X receptor,to regulate vitamin D target *** evaluated the relationship between VDR polymorphism and clinical characteristics associated with prostate cancer risk and prognosis among Egyptian *** and methods:This case-control study included 2 groups of patients:group A,a control group of 50 subjects with benign prostate hyperplasia,and group B,50 subjects newly diagnosed with prostate *** participants performed complete blood count,liver and kidney function tests,prostate specific antigen measurement,histopathological analysis and immunohistochemistry for Dickkopf Homolog *** fragment length polymorphism-polymerase chain reaction as performed to detect VDR ***:Patients with prostate cancer and controls showed a significantly different CA genotype frequency(p=0.007).Furthermore,prostate-specific antigen levels were significantly different in different genotypes in patients with prostate cancer(p0.001).Finally,T stage and the VDRApal C/A polymorphism were significantly associated(p0.041).Conclusion:The VDRApal C/A polymorphism may be a diagnostic and prognostic marker for prostate cancer in Egyptian men.