Preclinical characterization and anti-SARS-CoV-2 efficacy of ATV014:an oral cyclohexanecarboxylate prodrug of 1′-CN-4-aza-7,9-dideazaadenosine C-nucleoside

作     者：Qifan Zhou Sidi Yang Liu Cao Yang Yang Tiefeng Xu Qishu Chen Hongzhou Lu Yingjun Li Deyin Guo Xumu Zhang Qifan Zhou;Sidi Yang;Liu Cao;Yang Yang;Tiefeng Xu;Qishu Chen;Hongzhou Lu;Yingjun Li;Deyin Guo;Xumu Zhang

作者机构：Shenzhen Key Laboratory of Small Molecule Drug Discovery and SynthesisDepartment of ChemistryCollege of ScienceAcademy for Advanced Interdisciplinary Studies and Medi-X PingshanSouthern University of Science and TechnologyShenzhenGuangdong518000China Centre for Infection and Immunity Studies(CIIS)School of MedicineShenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong518107China Guangzhou LaboratoryBio-IslandGuangzhouChina Shenzhen Key Laboratory of Pathogen and ImmunityNational Clinical Research Center for infectious diseaseState Key Discipline of Infectious DiseaseShenzhen Third People′s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第2期

页      面：355-357页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by Shenzhen Science and Technology Program(JSGG20200225150431472,JSGG20210901145403012&KQTD20180411143323605) Guangdong Basic and Applied Basic Research Foundation(Grant#2020A1515110361) National Key Research and Development Program of China(#2021YFC0865100) Key-Area Research and Development Program of Guangdong Province(2021B1111110001) National Natural Science Foundation of China(grant#32041002,#82150206) D.G.is also supported by Guangdong Zhujiang Talents Program(#2016LJ06Y540)and National Ten-thousand Talents Program.The authors thank Lu Zhang,Ruyan Liao,Yongxia Shi and Jun Dai from Guangzhou Customs District Technology Center for the help in in vivo efficacy experiment.We also thank the other project participants,including Guanguan Li,Shuo Li and Xinjun Liu from Medi-X Pingshan,Southern University of Science and Technology for the support in preclinical study 

主　　题：respiratory acute clinical 

摘      要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of the global pandemic coronavirus disease 2019(COVID-19),has proven itself to be a highly virulent respiratory pathogen with an unpredictable evolutionary capacity,posing a persistent threat to *** the time of this manuscript’s publication.