Intratumoral microbiota:roles in cancer initiation,development and therapeutic efficacy
作者机构：Biotherapy CenterThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China School of Life SciencesZhengzhou UniversityZhengzhou450001P.R.China State Key Laboratory of Esophageal Cancer Prevention&TreatmentZhengzhou450052China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第2期
页 面：506-529页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by grants from the National Key Research and Development Program of China(No.2021YFE0110600) the National Natural Science Foundation of China(No.82072578,91942314,U1804281) the Outstanding Young Talents in Science and Technology Innovation of Henan Province(No.YXK2020027)
主 题：therapeutic immunity diagnosis
摘 要：Microorganisms,including bacteria,viruses,fungi,and other eukaryotes,play critical roles in human *** altered microbiome can be associated with complex *** microbial components are found in multiple tumor tissues and are closely correlated with cancer initiation and development and therapy *** intratumoral microbiota may contribute to promotion of the initiation and progression of cancers by DNA mutations,activating carcinogenic pathways,promoting chronic inflammation,complement system,and initiating ***,the intratumoral microbiota may not only enhance antitumor immunity via mechanisms including STING signaling activation,T and NK cell activation,TLS production,and intratumoral microbiota-derived antigen presenting,but also decrease antitumor immune responses and promote cancer progression through pathways including upregulation of ROS,promoting an anti-inflammatory environment,T cell inactivation,and *** effect of intratumoral microbiota on antitumor immunity is dependent on microbiota composition,crosstalk between microbiota and the cancer,and status of *** intratumoral microbiota may regulate cancer cell physiology and the immune response by different signaling pathways,including ROS,β-catenin,TLR,ERK,NF-κB,and STING,among *** viewpoints may help identify the microbiota as diagnosis or prognosis evaluation of cancers,and as new therapeutic strategy and potential therapeutic targets for cancer therapy.
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