Bacteria,inflammation,and colon cancer

作     者：Liying Yang Zhiheng Pei 

作者机构：Department of Pathology New York University School of Medicine New York NY 10016 United States Departments of Pathology and Medicine New York University School of Medicine New York NY 10016 United States Department of Pathology and Laboratory Medicine (113) Department of Veterans Affairs New York Harbor Health System NY 10010 United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第42期

页      面：6741-6746页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by US Public Health Service Grants, R01CA97946 and R01AI063477 and the Medical Research Service of the Department of Veterans Affairs, United States 

主　　题：Commensal bacteria Chronic inflammation Colon cancer Germfree mice Gene knockout 

摘      要：Our relationship with the colonic bacterial flora has long been viewed as benign, but recent studies suggest that this symbiosis has risks as well as benefits. This relationship requires that the host not only provide a supportive environment for the symbiotic bacteria, but also actively maintain intact mechanisms for properly managing the physiologic stresses that are closely associated with the symbiont’s essential survival functions. Failure to do so breaches the host- symbiont contract, and can result in serious effects on the health of the host. Recent investigations that employ several knockout mouse models reveal the consequences of genetic deficiency in the host regarding these mechanisms, and the latent, pro-inflammatory, tumorigenic nature of normal bacterial flora. Further study of the interactions between normal bacterial flora and hosts could shed light on the etiologies and pathogenesis of inflammatory diseases and related cancers, with implications for human health.