Evaluation of the use of rapid urease test:Pronto Dry to detect H pylori in patients with dyspepsia in several cities in Indonesia

作     者：AF Syam M Abdullah AA Rani S Nurdjanah P Adi A Djumhana P Tarigan IDN Wibawa 

作者机构：Division of Gastroenterology Department of Internal Medicine Dr. Cipto Mangunkusumo Hospital Faculty of Medicine University of Indonesia Jakarta 10430 Indonesia Division of Gastroentero-Hepatology Department of Internal Medicine Dr. Sardjito Hospital Faculty of Medicine Gajah Mada University Yogyakarta Indonesia Division of Gastroenterology Department of Internal Medicine Dr. Sutomo Hospital Faculty of Medicine Airlangga University Surabaya Indonesia Division of Gastroentero-Hepatology Department of Internal Medicine Dr. Hasan Sadikin Hospital Faculty of Medicine Padjajaran University Bandung Indonesia Division of Gastroentero-Hepatology Department of Internal Medicine H. Adam Malik Hospital Faculty of Medicine Sumatera Utara University Medan Indonesia Department of Internal Medicine Sanglah Hospital Faculty of Medicine Udayana University Denpasar Indonesia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第38期

页      面：6216-6218页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：尿素酶 幽门螺杆菌 消化不良 病理 

摘      要：AIM: To evaluate Pronto Dry examination in patients with dyspepsia. METHODS: The study was conducted in patients with dyspepsia who underwent endoscopic examination in several endoscopic centers of several cities in Indonesia from January 2003 until April 2004. Biopsies for histo- pathologic examination were fixed with formalin and sent to Histopathologic Department to be analyzed and confirm the presence of H pylori infection. If H pylori was found positive, the density was calculated semi quanti- tatively. Histopathologic examination from gastric biopsy samples was interpreted based on the updated Sydney system classification. RESULTS: Of 550 patients, 309 (56%) were male and 241 (44%) were female with ages ranging from 15 to 82 years. Mean age was 44.98 ± 14.46 years. Mean age of male patients was 44.35 ± 13.85 years and mean age of female patients was 45.78 ± 15.19 years. Evaluation of endoscopic results showed gastric ulcer in 36 cases (6.5%) and duodenal ulcer in 20 cases (3.6%). Normal endoscopic finding was found in 45 cases (8.2%) and minimal disorder of gastritis and duodenitis were found in 246 cases (44.7%). One case of gastric cancer was identified. Of 56 cases which were positive based on the criteria used, 39 patients were positive with Pronto Dry and 17 patients were negative with Pronto Dry. Overall sensitivity and specificity of Pronto Dry were 69.7% and 95.7% respectively. Positive predictive value was 66.1% and negative predictive value was 96.4% and overall ac- curate rate was 92.9%. CONCLUSION: Pronto Dry seems promising as a diag- nostic tool to detect H pylori more rapidly and accurately.