Relationships of body composition and adipocytokines with outcomes in metastatic castration-resistant prostate cancer patients receiving docetaxel chemotherapy
作者机构：Department of UrologyFudan University Shanghai Cancer CenterShanghai 200032China Shanghai Genitourinary Cancer InstituteShanghai 200032China
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2023年第25卷第4期
页 面：520-527页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported financially by the Medical Innovation Research Project of the Science and Technology Commission of Shanghai Municipality(20Y11905000) Natural Science Foundation of Science and Technology Commission of Shanghai Municipality(20ZR1412300) AoXiang Project of the Shanghai Anti-Cancer Association(SACA-AX202005)
主 题：adipocytokines body composition castration-resistant prostate cancer chemotherapy prognosis
摘 要：We evaluated the relationships of body composition and serum adipocytokine levels with progression-free survival(PFS)and overall survival(OS)in metastatic castration-resistant prostate cancer(mCRPC)patients receiving *** medical records of mCRPC patients who received docetaxel between January 2011 and December 2015 at Fudan University Shanghai Cancer Center(Shanghai,China)were *** following body composition parameters were calculated using computed tomography:skeletal muscle index(SMI),visceral adipose tissue index(VATI),and subcutaneous adipose tissue index(SATI).Pretreatment serum adipocytokine levels,including interleukin 6,insulin,leptin,monocyte chemoattractant protein-1,adiponectin,and resistin,were measured using the multiplex bead-based *** regression and Kaplan–Meier methods were used for survival *** the 453 mCRPC patients initially identified,105 were included in the *** VATI group patients had longer PFS(median,10 months vs 7 months,P=0.008)and OS(median,24 months vs 15 months,P=0.017),compared with low VATI group *** and SATI were not significantly associated with PFS or *** the six detected adipocytokines,only leptin was associated with mCRPC *** leptin group patients had shorter PFS(median,7 months vs 12 months,P=0.0018)and OS(median,17 months vs 22 months,P=0.042),compared with low leptin group *** analysis showed that a high VATI was an independent protective factor for PFS and OS,while a high leptin level was an independent risk factor for PFS and ***,VATI and serum leptin levels could provide important information concerning mCRPC prognosis.
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