Absorption of methionine sources in animals-is there more to know?

作     者：Philippe Becquet Mercedes Vazquez-Anon Yves Mercier Dolores I.Batonon-Alavo Frances Yan Karen Wedekind Tahir Mahmood Philippe Becquet;Mercedes Vazquez-Anon;Yves Mercier;Dolores I.Batonon-Alavo;Frances Yan;Karen Wedekind;Tahir Mahmood

作者机构：IMAABrusselsBelgium Novus InternationalSaint CharlesMissouriUSA Adisseo France SASAntonyFrance 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2023年第12卷第1期

页      面：159-170页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

主　　题：DL-Methionine Hydroxy-analog of methionine 2-Hydroxy-4-methylthiobutyric acid AbsorptionM ethodology 

摘      要：This literature review evaluates the absorption of methionine (Met) sources such as 2-hydroxy-4-methylthiobutyric acid (HMTBa), its calcium salts (HMTBa-Ca), and DL-methionine (DL-Met) by focusing on the state of knowledge regarding the absorption mechanism, experimental methodology, and factors affecting their absorption. The 2 Met sources differ in mechanism and site of absorption due to differences in their chemical characteristics and enzymatic conversion. This review addresses diffusion- and transport-mediated absorption systems for amino acids and carboxylic compounds, best elucidated by in vitro, ex vivo, and in vivo experimental models. Opportunities and limitations in the use of radioisotopes to depict absorption sites as well as host and microbial metabolism are described. Physiological and environmental conditions that lead to changes in gut absorptive capacity and the impact of Met source absorption are also evaluated. This review concludes that any comparison between HMTBa and DL-Met should consider their different behaviors during the absorption phase. Hence, the chemical characteristics of these 2 molecules entail different absorption sites and mechanisms, from passive absorption in the case of HMTBa and HMTBa-Ca to active transporters for DL-Met, HMTBa, and HMTBa-Ca. In addition, the different conversion modes of these 2 molecules further differentiate their absorption modes. Considering these important differences, it is easier to understand the apparent divergence between the conclusions of existing publications. When comparing these 2 molecules, it is recommended to properly adapt to the conditions under which the absorption of Met sources is evaluated.