Disturbed gut virome with potent interferonogenic property in systemic lupus erythematosus

作     者：Beidi Chen Jiabao Cao Wei Liu Yuqing Zhang Yudong Liu Min Wang Fei Xiao Jie Ma Jun Wang Xuan Zhang 

作者机构：Department of RheumatologyBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Division of Rheumatology and ImmunologyPeking University Third HospitalBeijing 100191China CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of SciencesBeijing 100101China The Key Laboratory of GeriatricsBeijing HospitalNational Center of GerontologyNational Health CommissionInstitute of Geriatric MedicineBeijing Institute of GeriatricsChinese Academy of Medical SciencesBeijing 100730China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2023年第68卷第3期

页      面：295-304,M0004页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Key R&D Plan of the Ministry of Science and Technology(2022YFC3602000) the National Natural Science Foundation of China(82230060,81788101,82201978,32141004,and 82171798) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29020000) the Chinese Academy of Medical Science Innovation Fund for Medical Sciences(CIFMS)(2021-1-I2M-017,2021-1-I2M-047,2021-1-I2M-040,2021-1-I2M-016,and 2021-1-I2M-026) the Capital’s Funds for Health Improvement and Research(2020-2-4019) 

主　　题：Systemic lupus erythematosus Gut virome Virus-like particles Interferon-a 

摘      要：Accumulating evidence suggests an essential role of disturbed gut microbiota in the etiopathogenesis of systemic lupus erythematosus(SLE),but it remains unclear as to gut *** this study,fecal virus-like particles(VLPs)isolated from 76 non-treated SLE patients and 75 healthy controls were subjected to gut virome *** proportion of bacteriophages was significantly elevated in the SLE gut,and the altered viral taxa were correlated with clinical *** virome and bacteriome were closely associated with each other in SLE *** combination of gut viral and bacterial markers displayed better performance in distinguishing SLE patients from healthy ***,VLPs from non-treated SLE patients promoted interferon-a production in an epithelial cell line and human immune ***,the interferon-stimulatory capacity diminished in VLPs from post-treated SLE *** findings may shed novel insights into SLE *** in-depth understanding of gut virome might help develop future biomarkers and therapeutics for SLE patients.